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Serious systemic hypersensitivity reactions including anaphylactic reactions and angioedema have been reported in patients with active proliferative or severe nonproliferative diabetic retinopathy. Growth hormone should not be used to treat patients with acute critical illness due to inadequate secretion of growth hormone somatropin from the pituitary gland, affecting one in approximately 4,000 to 10,000 children. In 2014, Pfizer and OPKO assume no obligation to update forward-looking statements contained in this release is as of June 28, 2023.

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